Fig. 2

Post stroke sodium butyrate treatment improves percent correct responses in the vibrissae-elicited forelimb placement test. a The same side test of the vibrissae-elicited forelimb placement task at 2 days shows both post-stroke saline- (MCAo + Sal) and NaB-treated (MCAo + NaB) animals display significantly reduced percent correct responses in the contralesional paw placement as compared to pre-stroke, but not in the ipsilesional side. b At 5 days post stroke, control treated animals showed significant deficits in paw-placement on the contralesional side compared to the pre-stroke test. NaB-treated animals showed no significant difference in contralesinal paw-placement pre and post stroke. No pre and post stroke differences were seen on the ipsilesional side. c, d In the cross-midline test of the vibrissae-elicited forelimb placement task, all groups showed reduction in correct responses at 2 days (c) and 5 days (d). (All graphs represent mean ± S.E.M. n = 7–9 in each group; ****p < 0.0001; paired t test between pre and post. a: main effect of time (pre and post), p < 0.05; b: main effect of treatment, p < 0.05; c: main effect of interaction, p < 0.05