Fig. 3

Sodium butyrate treatment improves the latency of tape removal post ischemia. a The latency (in seconds) to tape removal from the forepaw was evaluated before (pre) or after (2 days post) MCAo. Post-stroke performance on the ipsilesional paw in both saline- and NaB-treated animals was not significantly impaired at 2 days. However, post stroke performance on the contralesional paw was significantly worse in both groups. Latency to adhesive removal was significantly lower in the NaB treated group as compared to saline controls. b At 5 days post MCAo, post-stroke performance on the ipsilesional paw was not affected in either the saline- or NaB-treated animals. On the contralesional paw, post-stroke performance was significantly impaired in saline-treated animals, while no significant differences were found in post-stroke NaB-treated group. All graphs represent mean ± S.E.M. n = 7–9 in each group; *p < 0.05; paired t test between pre and post. a main effect of time (pre and post), p < 0.05; b main effect of treatment, p < 0.05; c main effect of interaction, p < 0.05