Fig. 2

Functional role of MASP-2 in pneumococcal meningitis mouse model. Kaplan-Meier curve showing increased survival in Masp2 ^−/− mice during pneumococcal meningitis (a). Cytokines and complement levels were measured in brain. Masp2 ^−/− mice had significantly lower brain levels of IL-1β, IL-10, and TNF-α 30 h after infection (b–d). Brain levels of C5b-9 were similar between Masp2 ^−/− and WT mice (e). Data are given as medians and 75th quartile; P values were determined with the Mann-Whitney U test