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Table 2 Serum and CSF parameters in HC, IgGOB−, and IgGOB+ patients

From: BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset

 

HC

IgGOB−

IgGOB+

Gender (F/M)

13/4

9/5

17/9

Age at LP (years)

43.2 ± 9.2

37.2 ± 10.7

38.2 ± 9.7

Disease duration (years)

n.a.

0.3 ± 0.6

0.6 ± 1.1

Csf-[Alb] (mg/dL)

17.0 ± 5.1

21.2 ± 8.7

23.1 ± 10.4

S-[Alb] (mg/dL)

4370.6 ± 379.0

4225.0 ± 297.7

4278.8 ± 355.6

QAlb (10−3)

3.9 ± 1.2

5.0 ± 2.0

5.4 ± 2.4*

Csf-[IgG] (mg/dL)

2.2 ± 0.9

2.4 ± 0.8

4.5 ± 1.8**** °°°°

S-[IgG] (mg/dL)

1141.2 ± 215.2

944.6 ± 124.2**

1094.3 ± 211.6°

QIgG (10−3)

1.9 ± 0.6

2.6 ± 1.0

4.2 ± 1.8**** °°

IgG Index

0.5 ± 0.1

0.5 ± 0.1

0.8 ± 0.3**** °°°

IgG Loc (mg/dL)

0.1 ± 0.3

0.2 ± 0.6

9.0 ± 11.5** °

IgIF (%)

0 ± 0

1.1 ± 2.7

16.4 ± 18.5*** °°

Leukocyte counts (/μL)

2.1 ± 1.1

2.9 ± 2.4

9.0 ± 8.6*** °

Csf -[BAFF] (pg/mL)

67.3 ± 21.6

69.9 ± 27.3

50.7 ± 20.5* °

BAFF Index

17.5 ± 5.2

13.2 ± 5.1

11.9 ± 6.1**

Csf-[CXCL13] (pg/mL)

0.9 ± 1.5

5.0 ± 8.2

27.7 ± 33.5*** °

Csf-[IL21] (pg/mL)

28.1 ± 29.1

21.6 ± 25.3

20.2 ± 21.9

  1. IgGOB+ patients differed from both BOIgG− and HC for intrathecal IgG synthesis parameters, CSF CXCL13 concentrations, and BAFF Index values. For gender, IgIF%, and IgGOB, chi square test was applied. For all the other variables, a t test was performed. Abbreviations as in Table 1
  2. P values compared to HC: *p < 0.5; **p < 0.01; ***p < 0.005; ****p < 0.001; p values compared to IgGOB−: °p < 0.5; °°p < 0.01; °°°p < 0.005; °°°°p < 0.001
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Journal of Neuroinflammation

ISSN: 1742-2094