Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Table 2 Correlation matrix between cognitive test scores with seed volume

Seed region	R entorhinal		L posterior cingulate		R frontoinsular		R dorsolateral prefrontal
MNI coordinates	(25,-9,-28)		(−2,-36, 35)		(38, 26,-10)		(44, 36, 20)
IL-1 beta genotypes	C-carrier	TT	C-carrier	TT	C-carrier	TT	C-carrier	TT
MMSE	0.189	−0.122	0.324**	0.451*	0.355**	0.464*	−0.039	0.489*
CASI total scores	0.140	−0.105	0.314**	0.391*	0.286**	0.393*	−0.027	0.530**
CASI EFT scores	0.109	−0.158	0.294**	0.344	0.219*	0.407*	0.000	0.510**
CASI Subdomains
Short Term Memory	0.085	−0.012	0.308**	0.275	0.335**	0.475*	0.064	0.401*
Orientation	0.136	−0.133	0.308**	0.376	0.342**	0.362	−0.044	0.457*
Long Term Memory	0.188	0.074	0.172	0.351	0.148	0.131	−0.041	0.485*
Language	0.155	−0.101	0.290**	0.394*	0.235**	0.255	−0.057	0.484*
Drawing	0.045	−0.040	0.058	0.389*	0.054	0.281	−0.078	0.472*
Attention	−0.013	−0.174	0.200	0.376	0.246**	0.421*	0.077	0.511
Verbal fluency	0.083	0.050	0.272**	0.406*	0.186	0.455*	−0.001	0.349
Abstract thinking	0.288**	−0.298	0.174	0.291	0.200**	0.141	0.030	0.478*
Mental manipulation	−0.018	−0.028	0.285**	0.159	0.074	0.424*	−0.091	0.367

Numbers indicate Pearson correlation coefficients, ^* p < 0.05; **p < 0.01
MMSE Mini-Mental State Examination, EFT executive function test, R right, L left, IL-1 interleukin-1, CASI Cognitive Abilities Screening Instrument, MNI Montreal Neurological Institute

ISSN: 1742-2094