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Table 1 Physiological variables for piglets in NT and HT groups

From: Systemic pro-inflammatory cytokine status following therapeutic hypothermia in a piglet hypoxia-ischemia model

Variables

Normothermia (NT) mean (SD)

Hypothermia (HT) mean (SD)

p Value

Post-natal age (h)

22.9 (0.9)

23.2 (0.8)

0.84

Body weight (g)

1583 (105)

1577 (91)

0.79

HR (bpm)

 Baseline

156 (12)

156 (12)

0.10

 End of insult

219 (55)

199 (55)

0.06

 2–26 h after time zero

162 (15)

132 (10)

0.10

 48 h after time zero

127 (12)

157 (19)

0.02

MABP (mmHg)

 Baseline

46 (4)

43 (7)

0.69

 End of insult

53 (8)

41 (6)

0.04

 2–26 h after time zero

48 (3)

42 (3)

0.07

 48 h after time zero

47 (11)

47 (10)

0.99

T rectal (°C)

 Baseline

38.8 (0.4)

38.7 (0.2)

0.82

 End of insult

38.5 (0.4)

38.5 (0.3)

0.11

 2–26 h after time zero

38.6 (0.1)

33.4 (0.2)

0.04

 48 h after time zero

38.4 (0.4)

38.6 (0.5)

0.30

pH

 Baseline

7.49 (0.05)

7.50 (0.07)

0.39

 Nadir of the insult

7.43(0.07)

7.49(0.11)

0.26

 12 h after time zero

7.48(0.08)

7.48(0.16)

0.10

 24 h after time zero

7.44(0.09)

7.47(0.11)

0.68

 48 h after time zero

7.41(0.17)

7.46(0.11)

0.99

BE (mmol/L)

 Baseline

6.5 (3)

9.1 (2.4)

0.46

 Nadir of the insult

1.3 (5.8)

4.5 (5)

0.16

 12 h after time zero

5.6 (1.3)

7.6 (4.1)

0.99

 24 h after time zero

4.9 (2)

7.5 (6.2)

0.63

 48 h after time zero

0.7 (3.2)

3 (2.9)

0.29

Lactate (mmol/L)

 Baseline

2.7 (1.9)

2.3 (0.9)

0.84

 Nadir of the insult

7.6 (2.9)

5.6 (2.1)

0.25

 12 h after time zero

1.4 (0.3)

1.2 (0.5)

0.77

 24 h after time zero

1.3 (0.5)

1.0 (0.3)

0.07

 48 h after time zero

1.8 (0.9)

1.5 (0.4)

0.93

Glucose (mmol/L)

 Baseline

7.2 (1.1)

7.0 (1.0)

0.11

 Nadir of the insult

9.0 (1.7)

8.5 (1.5)

0.36

 12 h after time zero

5.6 (2.3)

8.5 (3.5)

0.39

 24 h after time zero

4.6 (1.1)

5.2 (0.7)

0.39

 48 h after time zero

5.4 (0.6)

7.0 (7.8)

0.04

  1. Mean (SD) values are presented for each group. NT (n = 5) and HT (n = 6). Heart rate and blood pressure (mean arterial blood pressure; mmHg) data are omitted for 30 min after a saline/geoplasma bolus was administered or after cardiac arrest. Mann-Whitney analysis indicated the following in the HT group: a higher HR at 48 h (after rewarming), a lower MABP after HI (although still within the normal range), a lower temperature at 2–26 h (expected) and a higher blood glucose at 48 h