Fig. 1

miR-142-3p and miR-142-5p levels in human brain tissue samples and EAE spinal cords. Expression of microRNAs was measured in CNS tissues by real-time RT-PCR. The level of miR-142-5p was significantly increased in human MS samples compared with non-MS controls (a) (n = 6, Mann–Whitney U test, *p ≤ 0.05). EAE was induced in C57BL6 mice and spinal cord tissues were extracted at three time points after disease induction (b). Expression levels of miR-142a-3p and miR-142a-5p were significantly increased in spinal cord during the peak of disease and post peak phases of EAE (c). Data are shown as mean ± SEM. Number of mice in each group = 10, *p < 0.05, **p < 0.01, Kruskal–Wallis tests