Fig. 4
From: The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis
Pre-degranulation of mast cells reduces inflammation in duodenum and jejunum and weight loss of mice submitted to CPT-11-induced intestinal mucositis. a Pretreatment with c48/80 diminishes TNF-α levels in duodenum and jejunum of mice submitted to CPT-11-induced intestinal mucositis. b Pretreatment with c48/80 diminishes IL-6 levels in duodenum and jejunum of mice submitted to CPT-11-induced intestinal mucositis. c Pretreatment with c48/80 decreases iNOS mRNA expression in mice submitted to CPT-11-induced intestinal mucositis. Bars represent mean ± SEM of six mice in each group. # p < 0.05 versus control group, *p < 0.05 versus CPT-11 group. One-way ANOVA followed by Bonferroni. d Body weight changes are shown as percentages of the baseline value. Bars represent mean ± SEM of six mice in each group. # p < 0.05 versus control group, *p < 0.05 versus CPT-11 group. Two-way ANOVA followed by Bonferroni