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Table 2 The 23 genes significantly upregulated (threefold or more) in rat blood 3 days after traumatic brain injury (determined by qPCR array)

From: Exercise attenuates neurological deficits by stimulating a critical HSP70/NF-κB/IL-6/synapsin I axis in traumatic brain injury rats

Gene symbol

Accession number

Fold increase

Gene name

(EP + TBI + siRNA-vector)

(EP+ + TBI + siRNA-vector)

(EP+ + TBI + siRNA-HSP70)

Chemokines

 Ccl 2

NM_031530

3.5a

2.50

2.08

Chemokine (c-c motif) ligand 2

 Ccl 3

NM_013025

13.6a

7.45

8.76

Chemokine (c-c motif) ligand 3

 Ccl 17

NM_057151

5.9a

3.3

2.8

Chemokine (c-c motif) ligand 17

 Ccl 19

NM_057203

3.3a

−0.43

0.505

Chemokine (c-c motif) ligand 19

 Ccl 22

NM_057203.1

4.208a

1.446b

3.262c

Chemokine (c-c motif) ligand 22

 Cxcl 10

NM_139089

8.9a

3.95b

7.28c

Chemokine (c-x-c motif) ligand 10

 Cxcl 19

NM_001113651

3.3*

−0.43

0.50

Chemokine (c-x-c motif) ligand 19

 Ppbp

NM_153721

14.1a

9.56

10.69

Pro-platelet basic protein

Interleukins

 IL 18

NM_019165

19.3a

7.61b

14.74c

Interleukin-18

 IL 16

NM_031512

8.6a

4.86b

31.56c

Interleukin-16

 IL 1rn

NM_022194

2.41a

24.66

20.20

Interleukin 1 receptor antagonist

 IL 7

NM_008760860

26.9a

29.26

22.83

Interleukin 7

TNF (tumor necrosis factor receptor) superfamily

 Cd70

NM_001106878

20.1a

2.75b

10.96c

CD70 antigen

 Faslg

NM_012908

13.8a

8.01b

19.37c

Fasligand

 Ltb

NM_212507

8.1a

8.4

8.8

Lymphotoxin beta

 Tnfrsf 11b

NM_012870

14.3a

12.06

11.65

Tumor necrosis factor receptor superfamily, member 11b

Other cytokines

 Mif

NM_031051

11.9a

6.64b

10.14c

Macrophage migration inhibitory factor

Growth factors

 Bmp6

NM_013107

4.0a

15.26b

1.71c

Bone morphogenetic protein 6

 Bmp7

NM_001191856

3.8a

4.43

3.75

Bone morphogenetic protein 7

 Gpi

NM_207592

25.08a

27.34

25.43

Glucose-6-phosphate isomerase

Anti-inflammatory cytokines

 IL 10

NM_012854

3.70a

17.55b

2.91c

Interleukin 10

 IL 22

NM_001191988

3.22a

39.33b

7.97c

Interleukin 22

 IL 6

NM_012589

3.42a

12.49b

3.48c

Interleukin 6

  1. Data are from 8 control (sham) and 24 TBI rats. The fold increase for each parameter for (EP + sham + siRNA-vector) group rats is “1”
  2. Abbreviations: EP + Sham Sham rats that did not undergo exercise preconditioning (EP), EP + TBI EP that underwent a TBI, EP + + TBI EP+ rats that underwent a TBI, EP + + TBI + siRNA-vector EP+ rats were treated with vector and that underwent a TBI, EP + + TBI + siRNA-HSP70 EP+ rats were treated with siRNA-HSP70 and that underwent a TBI
  3. Only significant and annotated transcripts are included
  4. a(EP + TBI + siRNA-vector) vs. (EP + sham + siRNA-vector)
  5. b(EP+ + TBI + siRNA-vector) vs. (EP + TBI + siRNA-vector)
  6. c(EP+ + TBI + siRNA-HSP70) vs. (EP+ + TBI + siRNA-vector)