Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Table 1 Clinical parameters of rats subjected to EAE and treated with vehicle or SMI 6877002

Clinical parameter	Vehicle	SMI 6877002	Statistics
Incidence (%)	100	100
Survival (%)	100	100
AUC	10.6	8.7	P = 0.0804
Mean clinical score (day 13)	2.9	2.0	P = 0.1160
Mean day of onset	11.1	11.5	P = 0.4740
Mean peak disease severity	3.4	2.9	P = 0.0184
% Body weight loss (day 12 compared to day 0)	5.4	4.7	P = 0.2636

Treatment with SMI 6877002 reduced the cumulative score (AUC), the mean clinical score on day 13, and the peak disease severity compared to vehicle-treated rats. P values <0.05 were considered statistically significant, as determined by the non-parametric Mann-Whitney U test for disease scores or Student’s t test for body weight

ISSN: 1742-2094