Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Table 2 Clinical parameters of mice subjected to EAE and treated with vehicle or SMI 6877002

Clinical parameter	Vehicle	SMI 6877002	Statistics
Incidence (%)	93.3	100.0
Survival (%)	86.7	100	P = 0.1641
AUC	12.75	13.39	P = 0.3461
Mean clinical score (day 15)	2.9	2.8	P = 0.9257
Mean day of onset	12.1	12.6	P = 0.6487
Mean peak disease severity	3.4	3.3	P = 0.8853
% Body weight loss (day 16 compared to day 0)	12.2	12.1	P = 0.6548

Treatment with SMI 6877002 has no significant effect on clinical parameters of EAE in mice. P values <0.05 were considered statistically significant, as determined by the log-rank test for survival, the non-parametric Mann-Whitney U test for disease scores, or Student’s t test for body weight

ISSN: 1742-2094