Table 2 Spearman rank order correlations for PET amyloid deposition and immune profile in aMCI subjects
From: Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment
Cerebrospinal fluid (CSF) | Peripheral blood (PB) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | PET-PCC | PET-precuneous | PET-mean | Aβ42 | IL6 | IgG | CD4 T cell % | B cell % | Memory B cell% | Plasmab % | T cell # | CD4 T cell # | CD4:CD8 | CD4 T cell% | B cell % | CD4:CD8 | |
Age | 0.66** | 0.54* | 0.20 | −0.20 | −0.63* | −0.22 | − 0.49* | 0.29 | 0.39 | 0.60** | −0.28 | −0.30 | −0.39 | 0.10 | −0.32 | 0.07 | |
PET-PCC | (0.002) | 0.49* | 0.49* | −0.51* | −0.66* | 0.20 | −0.35 | 0.25 | 0.16 | 0.28 | −0.57* | − 0.54* | −0.20 | 0.16 | −0.28 | 0.12 | |
PET-precuneous | (0.013) | (0.029) | 0.73** | −0.36 | −0.45 | 0.002 | −0.39 | 0.10 | 0.38 | 0.39 | −0.12 | −0.21 | −0.22 | −0.34 | 0.58** | −0.32 | |
PET-mean | (0.39) | (0.027) | (<0.0001) | −0.52* | −0.06 | 0.04 | −0.31 | 0.09 | 0.56* | 0.18 | −0.13 | −0.22 | −0.05 | −0.33 | −0.43 | −0.35 | |
CSF | Aβ42 | (0.38) | (0.030) | (0.14) | (0.029) | 0.04 | −0.45* | 0.17 | −0.17 | −0.40 | −0.23 | 0.35 | 0.39 | 0.36 | 0.17 | 0.23 | 0.25 | |
CSF | IL6 | (0.027) | (0.038) | (0.19) | (0.88) | (0.90) | 0.17 | 0.68 | −0.02 | −0.51 | −0.52 | 0.16 | 0.13 | 0.34 | 0.01 | 0.57 | 0.14 | |
CSF | IgG | (0.33) | (0.44) | (0.99) | (0.88) | (0.04) | (0.62) | −0.10 | −0.19 | −0.39 | −0.16 | −0.35 | −0.25 | −0.01 | 0.29 | −0.06 | 0.22 | |
CSF | CD4 T cell (%) | (0.047) | (0.22) | (0.17) | (0.28) | (0.52) | (0.86) | (0.70) | −0.46 | −0.05 | −0.21 | 0.47 | 0.59* | 0.67** | −0.09 | 0.28 | −0.08 | |
CSF | B cell (%) | (0.21) | (0.34) | (0.69) | (0.72) | (0.46) | (0.95) | (0.44) | (0.06) | −0.02 | 0.17 | −0.47 | −0.56* | −0.18 | 0.09 | −0.16 | −0.01 | |
CSF | memory B (%) | (0.09) | (0.54) | (0.13) | (0.02) | (0.08) | (0.11) | (0.10) | (0.85) | (0.93) | 0.37 | 0.08 | 0.01 | −0.32 | −0.54* | −0.34 | − 0.63** | |
CSF | plasmablasts (%) | (0.005) | (0.28) | (0.12) | (0.49) | (0.33) | (0.10) | (0.50) | (0.42) | (0.47) | (0.11) | −0.04 | −0.08 | −0.49* | 0.09 | −0.43 | −0.08 | |
CSF | T cell (#) | (0.27) | (0.034) | (0.68) | (0.65) | (0.17) | (0.68) | (0.17) | (0.06) | (0.06) | (0.76) | (0.87) | 0.95** | 0.37 | −0.21 | 0.30 | −0.08 | |
CSF | CD4 T cell (#) | (0.25) | (0.046) | (0.47) | (0.44) | (0.12) | (0.74) | (0.34) | (0.01) | (0.019) | (0.99) | (0.75) | (<0.0001) | 0.50* | −0.14 | 0.09 | −0.03 | |
CSF | CD4:CD8 | (0.13) | (0.49) | (0.45) | (0.86) | (0.15) | (0.37) | (0.97) | (0.003) | (0.49) | (0.20) | (0.05) | (0.14) | (0.04) | 0.13 | 0.17 | 0.19 | |
PB | CD4T (%) | (0.68) | (0.56) | (0.20) | (0.22) | (0.48) | (0.97) | (0.22) | (0.73) | (0.72) | (0.026) | (0.74) | (0.41) | (0.60) | (0.63) | 0.20 | 0.94** | |
PB | B cell (%) | (0.13) | (0.23) | (0.007) | (0.06) | (0.30) | (0.05) | (0.79) | (0.28) | (0.49) | (0.14) | (0.06) | (0.24) | (0.72) | (0.51) | (0.40) | 0.18 | |
PB | CD4:CD8 | (0.76) | (0.65) | (0.22) | (0.19) | (0.31) | (0.70) | (0.37) | (0.75) | (0.99) | (0.007) | (0.77) | (0.76) | (0.91) | (0.45) | (<0.0001) | 0.18 | |