Fig. 2

Depressive symptoms mice exposed to CUMS. a Experimental design diagram. b Changes in body weight of mice. c Changes in blood sugar. d Content of 5-HT in hippocampus. e Road map of the open field experiment. f Ratio of distance between center and periphery. g Length of the total journey. h Center to peripheral delay time. i Path map of the morris water maze. j Escape latency. k Number of platform crossings. l Distance traveled in the correct quadrant. m Sugar water preference. n Forced to swim immobile time. o Tail suspension experiment immobility time. Each value represents the mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001 means difference of WT Control vs. WT CUMS, TPH2 KO vs. TPH2 KO CUMS, TPH2 KO vs. WT CUMS + FLX at the same point