Table 1 Animal and viral load information for vehicle or THC-treated chronic SIV-infected and uninfected rhesus macaques
Animal ID | SIV inoculum | Sex | Duration of infection | Plasma viral loads 106/mL | Brain viral loads 106/mg RNA | Brain histopathology | Colon viral loads 106/mg RNA |
|---|---|---|---|---|---|---|---|
Chronic SIV-infected and vehicle-treated (Group 1) (n = 11) | |||||||
IH96a,b,c,d,e,f | SIVmac251 | Male | 180 | 0.1 | 2 | ND | 786 |
HV48a,b,c,d,e,f | SIVmac251 | Male | 150 | 4 | 1 | ND | 147 |
IN24a,b,c,d,e,f | SIVmac251 | Male | 180 | 9.4 | 0.4 | ND | 29 |
JC81a,b,c,d,e,f | SIVmac251 | Male | 180 | 0.38 | 0.3 | ND | 320 |
JH47a,b,c,d | SIVmac251 | Male | 180 | 2 | 0.07 | ND | 300 |
JR36b,c,d | SIVmac251 | Male | 180 | 0.5 | 0.2 | ND | 20 |
JD66a,b,c,d | SIVmac251 | Male | 180 | 0.04 | 0.2 | ND | 4 |
IV95d | SIVmac251 | Male | 180 | 0.02 | 2.0 | ND | 2 |
HB31e | SIVmac251 | Male | 180 | 3000 | NA | SIV syncytia/encephalitis | 200 |
GA19e | SIVmac251 | Male | 180 | 100 | NA | ND | 600 |
FT11e | SIVmac251 | Male | 145 | 500 | NA | ND | 2075 |
Chronic SIV-infected and Δ9-THC treated (Group 2) (n = 11) | |||||||
GV60a,b,e | SIVmac251 | Male | 180 | 18.9 | 40,000 | SIV syncytia/encephalitis | 6726 |
HT48e | SIVmac251 | Male | 150 | 260 | 1750 | ND | 9360 |
IA83a,b,c,e,f | SIVmac251 | Male | 180 | 1.5 | 20 | ND | 1261 |
IH69a,b,e,f | SIVmac251 | Male | 180 | 0.06 | 3 | ND | 93.8 |
HI09a,b,c,e,f | SIVmac251 | Male | 180 | 0.01 | 0.04 | ND | 3.0 |
JB82a,b,c,e,f | SIVmac251 | Male | 180 | 7.7 | 2 | ND | 970 |
IA04a,b,c,e,f | SIVmac251 | Male | 150 | 0.66 | 1 | ND | 35 |
JI45c | SIVmac251 | Male | 180 | 3 | 0.01 | ND | 10 |
JT80c | SIVmac251 | Male | 180 | 1 | 0.04 | ND | 300 |
JC85c | SIVmac251 | Male | 180 | 0.02 | 0.09 | ND | 1 |
IV90c | SIVmac251 | Male | 180 | 0.02 | 0.06 | ND | 10 |
Uninfected controls (Group 3) (n = 38) | |||||||
HF34, HH69, HH75a,b,d | NA | Males | NA | NA | NA | NA | NA |
GV92, IR97a,d | NA | Males | NA | NA | NA | NA | NA |
KG97, LH65, MF62c | NA | Females | NA | NA | NA | NA | NA |
ML83, MM32c, JE51a,b,d | NA | Females | NA | NA | NA | NA | NA |
IT18, KF42, GT18d, GT20e | NA | Males | NA | NA | NA | NA | NA |
KD17d, EH70, EH80e | NA | Females | NA | NA | NA | NA | NA |
EL66, HT73, HT22, HN64e | NA | Males | NA | NA | NA | NA | NA |
LA88, LC39, LD08, LE67f | NA | Males | NA | NA | NA | NA | NA |
KV50 LA55, LA89, LB61f | NA | Males | NA | NA | NA | NA | NA |
LC48, LH75, LM56, LN60f | NA | Males | NA | NA | NA | NA | NA |
LH92, LI21, LI81, LM85f | NA | Males | NA | NA | NA | NA | NA |