Lipopolysaccharide-binding protein and future Parkinson’s disease risk: a European prospective cohort

Table 2 Association between plasma LBP levels and risk of PD

	PD cases plasma LBP (µg/ml)^a/n	Controls plasma LBP (µg/ml)^a/n	Odds ratio (95% CI)^b	p-value
Main analysis^c	26.9 (18.1–41.0)/352	24.7 (16.6–38.4)/352	1.46 (0.98–2.19)	0.061
Subgroup analysis by sex^c
Men	24.6 (18.1–38.9)/195	24.2 (16.9–39.3)/195	0.93 (0.55–1.59)	0.797
Women	29.6 (18.2–44.0)/157	25.4 (16.1–37.9)/157	2.68 (1.40–5.13)	0.003
Subgroup analysis by smoking status^d
Current smokers	29.7 (19.1–42.6)/43	23.0 (16.3–43.5)/55	1.12 (0.49–2.51)	0.793
Former smokers	24.2 (17.2–38.1)/116	25.4 (16.6–37.7)/110	1.09 (0.65–1.84)	0.736
Never smokers	27.8 (18.2–40.9)/183	24.4 (17.1–37.0)/174	1.30 (0.87–1.95)	0.198
Subgroup analysis by BMI^d
BMI < 25 kg/m²	22.7 (15.8–33.3)/119	24.5 (16.7–38.0)/137	0.78 (0.48–1.28)	0.331
BMI ≥ 25 kg/m²	29.6 (19.4–43.9)/233	24.8 (16.6–38.4)/215	1.54 (1.09–2.18)	0.016
Exclude cases diagnosed within 8 years^e	23.7 (16.3–40.1)/169	23.9 (16.1–37.3)/169	1.45 (0.79–2.65)	0.234
Include definite and very likely cases only^e	24.8 (17.1–40.8)/189	24.7 (16.6–39.6)/189	1.19 (0.69–2.07)	0.532
Exclude ELISA plates with high variability between duplicates^c	26.4 (18.2–39.7)/288	24.2 (16.6–36.8)/288	1.55 (0.99–2.41)	0.053

^aMedian (interquartile range)/the number of subjects
^bOdds ratio for one unit increase of naturally logarithmic LBP
^cConditional logistic regression for the matched case–control sets, adjusted for BMI and smoking status
^dMixed effects logistic regression, adjusted for age at recruitment, sex, study center, as well as BMI or smoking status when applicable, ELISA plate as random effect
^eMixed effects logistic regression, adjusted for age at recruitment, sex, study center, BMI and smoking status, ELISA plate as random effect

ISSN: 1742-2094