Fig. 4

A Mass spectrometry measurement of circulating histamine in the blood plasma of post-stroke animals with and without cromolyn treatment. Plasma levels of histamine at 24 h and 3 days post-stroke were significantly reduced after the cromolyn treatment. Data are expressed as median ± range, as well as individual values. B Increased levels of plasma IL-6 and C KC at 3 days after stroke when compared to age-matched shams. Cromolyn administration significantly downregulated both IL-6 and CXCL1 levels in the blood plasma post-stroke. Data are expressed as mean ± SEM as well as individual values, and are obtained from > 4 independent experiments at various times. Two-way ANOVA and Turkey’s multiple comparison show the statistical significance among the groups. *P < 0.05, **P < 0.01, ***P < 0.001