Fig. 10
From: iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype
AD-derived and healthy A iPSC-derived astrocytes and B iPSC-derived microglia-like cells were exposed to 488-fluorescent-Aβ42 fibrils for 2 h and phagocytosis was quantified through average fluorescent intensity per cell. The figure shows the percentage of B iPSC-derived astrocytes and D iPSC-derived microglia-like cells which show any uptake of Aβ42. The figure displays the mean ± SD of three cell lines with n ≥ 2 independent experiments per line. An unpaired t-test was used to test whether there were statistically significant differences between mean of AD-derived and healthy control astrocytes (*p < 0.05). Representative overlay of brightfield and fluorescent images of E iPSC-derived astrocytes and F iPSC-derived microglia-like cells, fluorescent Aβ42 fibrils shown in green, scale bar = 50 μm