Fig. 7
From: iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype
The concentration of A secreted IL-6 and B viability of AD-derived and healthy control astrocytes after stimulation with initially monomeric 0, 5 or 10 μM Aβ42 for 24 h. Cell lines were re-categorised based on their APOE ε3/ε3 (Ctrl-06, Ctrl-71 and fAD-08) or APOE ε3/ε4 (Ctrl-88, fAD-948 and fAD-950) genotype and shows the concentration of C secreted IL-6 and D viability after exposure to 0, 5 or 10 μM Aβ42 for 24 h. The figure displays the mean ± SD of three cell lines with n ≥ 2 independent experiments per line. A two-way ANOVA with post hoc Dunnett’s test was used to test whether there were statistically significant differences between mean of AD-derived and healthy control astrocytes and APOE ε3/ε3 and APOE ε3/ε4 astrocytes (**p < 0.01, ***p < 0.001)