Fig. 8

Multi-cytokine array of AD-derived or healthy iPSC-derived astrocytes A basally and B after 24 h exposure to 10 μM Aβ₄₂ and iPSC-derived microglia-like cells C basally and D after 24 h exposure to 10 μM Aβ₄₂. The figure displays the mean ± SD of three cell lines with the average of two experimental duplicates per line. Multiple unpaired, non-parametric Mann–Whitney t-tests adjusting for a 5% false discovery rate were used to test whether there were statistically significant differences between mean cytokine/chemokine release of AD-derived and healthy control astrocytes and microglia-like cells (*p < 0.05, **p < 0.01). Cytokines/chemokines with mean pixel density under 10% of the maximum in both basal and Aβ₄₂-stimulated conditions were considered background and are not shown, full cytokine array is shown in Additional file 1: Figs. S7 and S8