Table 1 Summary of iPSC line characteristics
From: iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype
iPSC line | Sex | Age at collection (years) | Disease status | APOE genotype1 | Origin tissue | Reprogramming method |
|---|---|---|---|---|---|---|
Ctrl-06 | F | 82 | Healthy control | ε3/ε3 | Fibroblast | Episomal plasmid |
Ctrl-71 | F | 61 | Healthy control | ε3/ε3 | Fibroblast | Episomal plasmid |
Ctrl-88 | M | 57 | Healthy control | ε3/ε4 | Fibroblast | Episomal plasmid |
fAD-08 | F | 81 | Alzheimer’s(PSEN2 N141I) | ε3/ε3 | Fibroblast | Episomal plasmid |
fAD-948 | F | 40 | Alzheimer’s (PSEN2 N141I) | ε3/ε4 | Fibroblast | mRNA |
fAD-950 | F | 37 | Alzheimer’s (PSEN2 N141I) | ε3/ε4 | Fibroblast | mRNA |