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Fig. 2  | Journal of Neuroinflammation

Fig. 2 

From: Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons

Fig. 2 

Differential expression of innate immune genes and LDLRAD3 in OSN. A Reanalysis of scRNA-seq data set (Ziegler et al., 2020) which captured a large population of both immature and mature murine OSN. Heatmap of DEGs belonging to GO terms (Innate Immune Response, Response to Virus, Response to Type-1 Interferon, Response to Interferon Alpha, and Response to Interferon Beta (N = 1816 mOSN, 539 iOSN from two mice). B Violin plot of expression of candidate genes relevant to VEEV infection and interferon signaling in mature and immature OSN. C FISH of Ldlrad3 (gray) expression in OMP+ (red) and GAP43+ (green) OSNs within the ONE. Images depict representative staining from N = 3 mice. P values are indicated

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Journal of Neuroinflammation

ISSN: 1742-2094