Fig. 2
Strong correlation between intraepidermal nerve fibres and associated Schwann cells in murine plantar skin. Male and female mice underwent chronic constriction injury (CCI) or sham surgery. Hind paw foot pads were harvested 7 days after surgery and intraepidermal nerve fibre density (IENFD), and the density of intraepidermal Schwann cell processes were determined. A IENFD and B associated Schwann cell numbers are plotted (Welch’s ANOVA and Dunnett’s tests, nSham = 6, nCCI IL = 8, nCCI CL = 8). C Pearson correlation between IENFD and Schwann cell process density in all skin samples (n = 22). Data are shown as mean ± SD. CL: contralateral; IL: ipsilateral