Fig. 4
Preserved intraepidermal nerve fibre and Schwann cell innervation in CRPS affected skin. Skin sections from the index finger were immunolabelled to assess A intraepidermal nerve fibre density (IENFD, nHC = 25, nacute = 19, nchronic = 6) and B intraepidermal Schwann cell process density in patients with acute and chronic CRPS and HC (nHC = 24\1, nacute = 19, nchronic = 6). C Correlation of IENFD and Schwann cell process density in all skin samples (n = 75). D Ratio of Schwann cell processes and IENFs (nHC = 25, nacute IL = 18\1, nacute CL = 16\3 nchronic = 6). Data are presented as median ± interquartile range (Kruskal–Wallis and Dunn’s tests). CL: contralateral; HC: healthy controls; IL: ipsilateral