Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease

Fig. 5

Estrogen receptor signaling regulates Rac and Rho GTPase signaling network by altering the global DNA methylation profile. A Volcano plots illustrating the DNA methylation profiles of the MCF-7 cell line subjected to estrogen-deprived (left) or replete (right) conditions. B UpSet plot summarizing the total and intersecting hyper- or hypomethylated locus numbers identified in A. C Pathway enrichment analysis of 1125 estrogen-responsive DNA methylation gene loci identified from A. The top enriched pathways are labeled. D Volcano plots showing the changes in DNA methylation profiles in brain tissues of LOAD versus ND individuals in a sex-specific manner (left: female; right: male). E, F Estrogen-responsive DNA methylation gene loci revealed significant overlap with altered DNA methylation loci found in female LOAD patient samples, illustrated as E Venn diagram and F heatmap formats. G Pathway enrichment analysis of estrogen-responsive hypomethylated (left) and hypermethylated (right) genes identified in female LOAD subjects

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094