Fig. 2From: MIF contribution to progressive brain diseasesMIF in AD. Activated glia and especially neurons are the main sources of MIF in AD. Dysregulated glucose metabolism and AGE promote MIF conformational changes leading to disrupted ERK signaling in glia cells. In AD increased CD74 has been found in microglia, neurofibrillary tangles, amyloid β plaques and neuronsBack to article page