Fig. 4

MIF and D-DT inhibition in MS. MIF and D-DT signaling through CD74 is involved in MS progression by increasing inflammatory cell migration to the CNS, enhancing secretion of pro-inflammatory cytokines and prolonging survival of pro-inflammatory cells. Inhibition of MIF or D-DT signaling by partial MHC constructs (DRQ), ISO-1 or ibudilast attenuates signs of MS progression