Fig. 3
From: Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice
Interaction between NLRP1 and mTOR in the hippocampus. A–D Representative images (A) and quantification of NLRP1/mTOR per unit area show that CSDS (10 d) exposure facilitated the colocalization (arrows) between NLRP1 and mTOR in the hippocampal CA1 (B), CA2 (C) and CA3 (D) region. Scale bar = 100 μm. E Representative immunoreactive bands show that NLRP1 is immunoprecipitated with mTOR but not PI3K/AKT and CSDS (10 d) exposure promoted the immunoprecipitation between NLRP1 and mTOR in the hippocampus. IgG is a negative control. Data represented the mean ± SEM, n = 3, *p < 0.05, **p < 0.01 vs. control group