Fig. 1

C-Mito were functionally compromised and oxidatively damaged in HF mice. A Representative photomicrographs of C-Mito under transmission electron microscopy. Scale bar = 50 nm. B Nanoparticle tracking analysis of C-Mito. C Respiratory complexes activity assays were performed to evaluate the function of respiratory chain of C-Mito. D JC-1 probe was used to detect the membrane potential of C-Mito. E Mito-SOX probe was used to detect the ROS level of C-Mito. F BODIPY 581/591 probe was used to evaluate the lipid peroxides level of C-Mito. n = 8, P < 0.05, t test.