Fig. 9

C-Mito^HF aggravated myocardial sympathetic hyperinnervation depended on the SFO endothelial cGAS in HF mice. Immunofluorescent staining results showed that, compared to C-Mito^Ctrl, C-Mito^HF exacerbated sympathetic hyperinnervation in the myocardium of HF mice, shown by increased TH-positive nerve fibers (A, B) and GAP43 positive sprouting nerves (C, D), which could be ameliorated by endothelial cGAS KD in the SFO of HF mice. Scale bar = 150 μm. n = 8, P < 0.05, ANOVA LSD test