Fig. 3

Gene expression findings from the ipsilateral cortex suggesting interactive effects of T.gondii and CCI at 2-h post-injury in male and female mice. In both males (A–D) and females (E–P), there was evidence that combined T. Gondii and CCI resulted in altered pathophysiology relative to T. gondii and/or CCI in isolation at 2-h post-injury. This includes genes reflective of inflammatory mediators (A–G, I–P), and astrogliosis (H). B, O and P were analyzed with 2-way ANOVA and the significant T. Gondii * CCI interaction was further analyzed with Bonferroni post-hoc comparisons. These normally distributed data are displayed as mean ± SD. Data in A and C–N were not normally distributed and were therefore analyzed with Kruskal–Wallis tests and presented as median with interquartile range. *p < 0.05, **p ≤ 0.01. ***p ≤ 0.001