Fig. 4

Gene expression findings from the ipsilateral cortex suggesting interactive effects of T. gondii and CCI at 24-h post-injury in male mice. Relative to T. gondii and/or CCI in isolation, male mice with combined T. Gondii and CCI had evidence of altered gene expression related to neuroinflammation (A–D, F, G), oxidative stress (E), neuronal integrity (H), and glutamatergic pathways (I, J). I and J were analyzed with 2-way ANOVA and the significant T. Gondii * CCI interaction was further analyzed with Bonferroni post-hoc comparisons. These normally distributed data are displayed as mean ± SD. Data in A–H were not normally distributed and were therefore analyzed with Kruskal–Wallis tests and presented as median with interquartile range. *p < 0.05, **p ≤ 0.01. ***p ≤ 0.001