Fig. 7

MRI analysis of lesion volume and white matter tract abnormalities 18-weeks post- injury. 3D multi-gradient echo images were acquired through ex-vivo MRI for male (A) and female (B) mice to assess lesion size in the ipsilateral cortex. In males, the CCI groups had larger lesions than sham groups; however, the T. gondii + CCI mice also had a larger lesion volume than the Vehicle + CCI mice (C). In females, CCI mice had larger lesions than sham-injured groups but, unlike males, no difference was found between T. gondii + CCI and Vehicle + CCI groups (D). Whole-brain statistical testing with connectivity based fixel enhancement revealed that T. gondii + CCI males had white matter tract abnormalities that spanned both hemispheres when compared to Vehicle + CCI males (E). In females, more subtle differences in the contralateral corpus callosum were observed between T. gondii + CCI and Vehicle + CCI groups (F). Data displayed as mean ± SD. *p < 0.05, ***p ≤ 0.001. n = 6–7/ group/ sex