Table 5 Mechanisms of mitochondrial and metabolic dysfunction influencing neutrophil function
From: Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis
Mechanism of mitochondrial and metabolic dysfunction | Neutrophils functions | References |
|---|---|---|
Knock-out CXCR2 reduces ROS production through inhibiting Ncf1 and IL-1β production | Reduce the inflammatory cytokines | [143] |
Deficiency of Socs3 elevates ROS through activating G-CSF/STAT3 signaling | Enhance neutrophil activation | [144] |