Fig. 1
Widespread pain was induced by CCI-ION rats’ CSF. A The escape threshold of vibrissal pad to mechanical stimuli in the sham and CCI-ION groups. Two-way ANOVA, ****p < 0.0001, n = 6/group. B The paw withdrawal threshold to thermal stimuli in the sham and CCI-ION groups. Two-way ANOVA, ****p < 0.0001, n = 6/group. C The paw withdrawal threshold to mechanical stimuli in the sham and CCI-ION groups. Two-way ANOVA, **p < 0.01, ***p < 0.001, n = 6/group. D The schematic diagram of CSF transplantation. E The workflow of i.c. injection CCI-ION rats’ or sham rats’ CSF and behavioral tests. F The mechanical escape threshold of vibrissal pad in rats receiving sham CSF or CCI-ION CSF. Two-way ANOVA, ***p < 0.001, ****p < 0.0001, n = 7/group. G The thermal withdrawal threshold of hind paw in rats receiving sham CSF or CCI-ION CSF. Two-way ANOVA, *p < 0.05; **p < 0.01; ****p < 0.0001, n = 7/group. H The mechanical allodynia of hind paw in rats receiving sham CSF or CCI-ION CSF. Two-way ANOVA, *p < 0.05; ****p < 0.0001, n = 7/group