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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation

Fig. 2

P2X7R expression was significantly elevated in CD4+ T cells in EAN rats. P2X7R expression in T cells and macrophages in control (unimmunized group) and EAN rats at day 18. (A-B) Fluorescence photomicrographs showing P2X7R expression and quantification in CD4+ T cells, CD8+ T cells and macrophages (CD68+) in the sciatic nerves of EAN and control rats. Scale bars, 20 μm. (C) Graph showing the number of P2X7R-positive cells in sciatic nerve sections obtained from control and EAN rats. (D-E) Flow cytometry analysis of P2X7R expression and quantification on CD4+ T cells, CD8+ T cells and macrophages in the spleen of EAN and control rats. Experiments were performed in triplicate (n = 6 per replicate) with similar results. *p < 0.05, **p < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094