Fig. 2

Microglia Reorganize to Compensate for Cell Loss Following Cranial Irradiation. A Percent change in the average nearest neighbor distance for microglia in control and Irradiated mice over time. Histograms showing the distribution of microglia nearest neighbor distances at B Week 1, C Week 2, D Week 3, and E Week 4 for control and irradiated mice. F Percent change in spacing index (squared average NND multiplied by the density for each image) for control and Irradiated mice over time. Mixed-effects analysis with Bonferroni’s post-hoc comparisons (A, F) or two-way ANOVA with Bonferroni’s post-hoc comparisons (B–E). * = p < 0.05, ** = p < 0.01. Data are presented as mean ± SEM. Each data point represents an individual animal. n = 7–10 mice per timepoint per group