Fig. 6

Anxiety-like behaviour in elevated plus maze reveals open arm avoidance by P2RY12-deficient female mice. A A sketch of the elevated plus maze (EPM) used to assess anxiety-like behaviour. B P2RY12-deficient females displayed a significance preference for avoiding the open arms. A trend towards a sex-genotype interaction was also observed. C While trends were noted in the effects of genotype and in post hoc analysis among females, no significance difference was found in the time spent in the closed arms of the EPM. D Analysis revealed main effects of genotype and sex on the distance traveled in the closed arm. Statistical analysis was performed using 2-way ANOVA followed by Tukey’s multiple comparisons test. Data are presented as mean ± SEM, with p < 0.05 indicating statistical significance. N = 8–12 mice per group. *p denotes p < 0.05. OA = open Arm, CA = closed Arm