Fig. 7From: Schwann cell-derived extracellular vesicles promote memory impairment associated with chronic neuropathic painSchematic overview of the injured sciatic nerve-brain communication pathway that modulates dendritic spine remodeling in the hippocampus. Pathological Schwann cells-derived EVs and their cargo miR-142-5p mediate Schwann cells interorgan communication, inducing  dendritic spine damage and memory impairment associated with chronic neuropathic pain.Back to article page