Fig. 4

NSA or Mdivi-1 reversed mitochondrial abnormalities in the hippocampus of SAE mice. A Representative images of mitochondria ultrastructure surrounding the nuclei, the black arrow showed the interruptions of continuity of mitochondrial membrane. B Representative images of mitochondria ultrastructure in the hippocampal CA1 region. The asterisks showed the abnormal mitochondria. C Quantification of the abnormal mitochondria. Data are presented as the mean ± SEM (n = 3 mice/group, three images per mouse). Magnification 10,000 ×. Scale bar = 1 μm. D ROS levels in the hippocampus. Data are presented as the mean ± SEM (n = 4–5 mice/group). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus the indicated groups