Fig. 8

The schematic diagram illustrates that CLP induces the activation of GSDMD and subsequently increases Drp1, leading to mitochondrial injury, significant neuronal and synaptic damage, and a decrease in neural oscillations in the hippocampus, ultimately contributing to cognitive impairments. Notably, inhibiting GSDMD/Drp1 pathway might reverse these aberrant changes and ameliorate cognitive deficits in SAE mice