Fig. 2

H151 inhibited STING activation and promoted post-stroke recovery of motor function. A Representative bands of phospho- and total-TBK1, as well as β-ACTIN using Western Blotting experiments. B The relative expression levels of phospho- and total-TBK1. β-ACTIN was used as the internal reference. The results were relative to sham + vehicle group. C The protein levels of IFNβ detected by ELISA. D The relative mRNA levels of interferon-stimulated genes (Oasl2, Isg15, and Ifit3). The results were relative to sham + vehicle group. n = 4–7 mice per condition. Each dot represented an individual mouse. E The quantification of foot fault rate in grid walking test at different time points after photothrombotic stroke. F The quantification of forelimb asymmetry in cylinder test. G The time spent by the injured forelimb to sense the adhesive tape in adhesive removal test. H The time to remove tape in adhesive removal test. n = 12–13 mice for behaviour assessment. Data were presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ns: not significant