Fig. 10
Schematic diagram for Fascin-1 limiting myosin activity to control spinal cord stiffness during microglial migration. In Fascin-1fl/fl mice, Fascin-1 inhibits myosin activity to promote microglial migration. Microglia are involved in injury core mechanical signaling changes that soften the tissue. In Fascin-1 CKO mice, myosin activity in microglia is increased, driving microglial migration down. The decrease of migration restrains spinal cord tissue softening. Reducing myosin activity rescues microglial migration and tissue softening in Fascin-1 CKO mice