Fig. 7
Fascin-1 deletion in microglia enhances myosin activity after SCI. (A) Sagittal immunofluorescence images of pMRLC (green), CXRCR1 (red), and DAPI (blue) from Fascin-1fl/fl and Fascin-1 CKO mice before SCI and at 7 and14 dpi. The regions of interest (ROI) represent the boxed regions on the left. The lesion core was marked with the asterisks. Scale bar: higher magnification, 20 μm; low magnification, 100 μm. (B) Percentage quantification of pMRLC+CX3CR1+ cells in relation to the overall CX3CR1+ cells. n = 3 animals in (B). ns, no significance; ***P < 0.001, ****P < 0.0001 by two-way ANOVA