Fig. 1

Differentially displayed transcripts in CD11b⁺ and ACSA2⁺ cells purified from the striatum and the midbrain after subacute or chronic MPTP intoxication. (A) Scheme of the two MPTP intoxication protocols used. In the subacute regimen (sMPTP), mice received 5 consecutive MPTP doses and in the chronic administration (cMPTP) animals received 10 MPTP doses along 5 weeks. Control mice were injected with the MPTP vehicle or MPTP vehicle with probenecid following the same MPTP administration pattern. sMPTP mice were sacrificed 24 h and cMPTP 48 h after the last MPTP injection. CD11b⁺ and ACSA2⁺ were purified from the striatum and the ventral midbrain for bulk RNA sequencing. (B) Venn diagrams representing differentially displayed genes (p < 0.01) in sMPTP and cMPTP animals with respect to their corresponding controls. (N = 3 animals/group). Str: striatum; Mdb: ventral midbrain