Fig. 10
From: Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity
Summary of the networks predicted to be altered in human microglia and astrocytes in the midbrain. Differentially displayed genes in human glia obtained from the midbrain of PD patients were subjected to Ingenuity Pathway Analysis (IPA). The graphical summary represents the pathways, upstream regulators and biological functions predicted to be altered (A) in microglia and (B) astrocytes. The results of IPA analyses of human, sMPTP and cMPTP glial cells in the midbrain were subjected to Ingenuity Comparison Analysis to compare the z-scores of upstream regulators, pathways and biological functions in (C) microglia and (D) astrocytes