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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Chronic immunosuppression across 12 months and high ability of acute and subacute CNS-injury biomarker concentrations to identify individuals with complicated mTBI on acute CT and MRI

Fig. 4

ROC curves indicating diagnostic accuracy for the algorithmically selected biomarker combinations discriminating CT + and MRI + patients. ROC curves are based on the optimal combination of biomarkers for predicting CT + and MRI + patients at each timepoint. AUC values for each timepoint are indicated in the plot. Biomarkers included for findings on CT: Admission: GFAp, NFL, MIP-1β, IP-10, eotaxin, IL-ra; 2 weeks: GFAp, NFL, MIP-1β, IP-10, eotaxin, IL-ra 3 months: NFL, MIP-1β, IP-10. 12 months: MIP-1β, IP-10. Biomarkers included for findings on MRI: Admission: GFAp, NFL, MIP-1β, IP-10, eotaxin; 2 weeks: GFAp, NFL, MIP-1β, IP-10, eotaxin 3 months: NFL, MIP-1β, IP-10. 12 months: MIP-1β, IL-9. ROC, Receiver Operating Characteristic; AUC, Area Under the Curve; GFAP = Glial fibrillary acidic protein; NFL = Neurofilament light; IFNγ = Interferon Gamma; IL = Interleukin; MIP = Macrophage Inflammatory Protein; MCP = Monocyte Chemoattractant Protein; IP = IFNγ-induced Protein; TNF = Tumor Necrotic Factor; FGF-basic = Basic Fibroblast Growth Factor; PDGF = Platelet-derived Growth Factor

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Journal of Neuroinflammation

ISSN: 1742-2094