Fig. 9
From: Complement propagates visual system pathology following traumatic brain injury
Summary Schematic. Controlled cortical impact induces complement deposition on retinogeniculate synapses, microglial morphological changes and internalization of synapses. This is associated with complete vision loss in the contralateral eye and partial visual acuity loss in the ipsilateral eye. Injury-site targeted complement inhibition with CR2-Crry reduces complement deposition, attenuates microglial morphological changes and reduces synaptic internalization, which is accompanied by improvement in visual acuity in the ipsilateral eye. Figure created in BioRender