Fig. 7

The Nrf2/ERK signaling pathway is involved in mediating OI-driven neurogenesis. a Representative immunostaining images of DCX (green) and EDU (red) in the hippocampal DG region. b–d Quantification of EDU and DCX positively stained cells. e Representative TUNEL immunostaining images in the hippocampal DG region. f Statistics of TUNEL-positive cells. g Representative immunostaining images of DCX (green) and p-ERK (red) in the hippocampal DG region. h Quantification of DCX and p-ERK positively stained cells. i Immunofluorescence staining of p-ERK (red) and MAP2 (green) in primary neurons. j Quantification of integrated density of p-ERK in the primary neurons. Data are expressed as mean ± SD. n = 4. *P < 0.05, **P < 0.01, and ***P < 0.001 by one-way ANOVA