Fig. 6

AVE0991 treatment increased the phenotypic switch of microglia/macrophages from pro‑inflammatory to regulatory phenotype. A Representative double immunofuorescence staining for Iba1 (green) and CD16/32 (red), iNOS (red), Arg1 (red) and CD163 (red) in the perihematomal area. Scale bar = 50 μm. B–E Quantitative analyses of Iba1 + CD16/32 microglia/macrophage, Iba1 + /iNOS + pro‑inflammatory microglia/macrophage and Iba1 + /Arg1 + , Iba1 + /CD163 + regulatory microglia/macrophage in the perihematomal area at 3 days after ICH. Data were represented as mean ± SD. ***P < 0.001 vs. Sham; ^###P < 0.001 vs. ICH + Vehicle; n = 6/group. AVE, AVE0991