Table 1 Effects of native apolipoprotein E isoforms on fibrillogenesis of Aβ1-40 and Aβ1-42. Fold-effects represent means ± SEM of the quotients of ThT fluorescence values obtained for each Aβ peptide in the presence of apolipoprotein E-isoform-containing conditioned medium divided by ThT values obtained in the presence of conditioned medium lacking apolipoprotein E, derived from empty vector-transfected cells (n = 5–6).
From: Similar promotion of Aβ1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms
Aβ1-40 | |||
|---|---|---|---|
1 day co-incubation | CHO apolipoprotein E ε3 | 1.0 ± 0.l-fold | N.S. |
CHO apolipoprotein E ε4 | 1.0 ± 0.l-fold | N.S. | |
7 day co-incubation | CHO apolipoprotein E ε3 | 1.0 ± 0.l-fold | N.S. |
CHO apolipoprotein E ε4 | 1.2 ± 0.l-fold | N.S. | |
Aβ1-42 | |||
4 day co-incubation | CHO apolipoprotein E ε3 | 1.7 ± 0.27-fold | p < 0.01 |
CHO apolipoprotein E ε4 | 1.6 ± 0.18-fold | p < 0.005 | |
7 day co-incubation | CHO apolipoprotein E ε3 | 1.7 ± 0.22-fold | p < 0.005 |
CHO apolipoprotein E ε4 | 1.8 ± 0.19-fold | p < 0.0005 | |